Birth complications add schizophrenia risk

U.S. scientists have identified four genes that interact with serious
obstetric complications to increase the risk for schizophrenia.

National Institute of Mental Health researchers in Bethesda, Md.,
examined 13 genes believed to play a role in the development of
schizophrenia. All of the genes also play a role in supplying blood to
the brain, or are influenced by hypoxia -- a condition in which
insufficient oxygen is present for proper cellular functioning.

A subset of individuals tested had experienced at least one serious
obstetric complication, many having the potential to lead to hypoxia.

The researchers determined individuals who had four specific genetic
variations, and who also had experienced at least one serious
obstetric complication, were significantly more likely to develop
schizophrenia as adults.

The study appears in the online issue of the journal Molecular
Psychiatry.

Copyright 2008 by United Press International
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