HOWE COME You Fear And Hate The Freakin Simply Amazing Puppy Wizard <{); ~ ) >
HOWE COME You Fear And Hate
The Freakin Simply Amazing Puppy Wizard <{); ~ ) >
HOWEDY DaveR,
DaveR wrote:
> What if the Puppy Wizard was actually a nice guy,
"Nice guys finish LAST", DaveR. NICE GUYS PLAY GRABBASS
with liars dog abusers cowards and active acute chronic
long term incurable mental cases and PERPETUATE the system
of lies and abuse <{); ~ ) >
"Thank you for fighting the fine fight--
even tho it's a hopeless task,
in this system of things.
As long as man is ruling man,
there will be animals (and humans!)
abused and neglected. :-(
Your student," Juanita.
> and a sane person,
Your PALS jerk choke shock bribe crate intimidate
surgically sexually mutilate and murder innocent
defenseless dumb critters an LIE abHOWET it <{): ~ ( >
"The greatness of a nation and its moral progress
can be judged
by the way its animals are treated."
~ Mohandas Gandhi --
Adapted with permission from his FREE
copy of The Puppy Wizard's FREE Wits'
End Dog Training Method Manual. <}TPW ; ~ ) >
Force training JERRYIZES dogs...
and GETS THEM DEAD.
"Of all tyrannies, a tyranny exercised
for the good of its victims,
may be the most oppressive.
Those who torment us for our own good
will torment us without end,
for they do so with the approval of
their own conscience." -
- C.S. Lewis.
"Death is better, a milder fate than tyranny",
Aeschylus (525BC-456BC),
Agamemnon
> and actually presented his advice
"The Methods, Principles And Philosophy Of Behavior
Never Change,
Or They'd Not Be Scientific And Could Not Obtain
Consistent, Reliable, Fast, Effective Results
For All Handler's And All Dogs
AND ALL BEHAVIORS
ALL OVER The WHOWEL WILD WORLD
NEARLY INSTANTLY,
As Taught In Your Own FREE Copy Of The Simply Amazing
Puppy Wizard's 100% CONSISTENTLY NEARLY INSTANTLY
SUCCESSFUL FREE WWW Wits' End Dog Training Method Manual,"
The Freakin Simply Amazing Puppy Wizard. <{} ; ~ ) >
> in a constructive and courteous manner,
Like HOWE it was when Jerry Howe first posted here abHOWETS.
THE MENTAL CASES CALLED HIM A LIAR.
"Only the unenlightened speak of wisdom and right action
as separate, not the wise.
If any man knows one, he enjoys the fruit of both.
The level which is reached by wisdom
is attained
through right action as well.
He who perceives that the two are one knows the truth."
"Even the wise man acts in character with his nature,
indeed all creatures act according to their natures.
What is the use of compulsion then?
The love and hate which are aroused by
the objects of sense
arise from Nature, do not yield to them.
They only obstruct the path," -
- Bhagavad Gita, adapted by
Krishna with permission from
His FREE copy of The Puppy
Wizard's FREE Wits' End Dog
Training Method manual <{) ; ~ ) >
In The Problem Animal Behavior BUSINESS
FAILURE MEANS DEATH.
SAME SAME,
For The Problem Child Behavior BUSINESS.
> with no personal attacks or ridiculous rants?
The Freakin Simply Amazing Puppy Wizard came here to
IDENTIFY EXXXPOSE and DISCREDIT the professional lyin
dog abusing punk thug cowards NICE GUYS like YOU are
playin grabbass with DaveR <{); ~ ) >
"If you talk with the animals, they will talk with you
and you will know each other.
If you do not talk to them, you will not know them,
and what you do not know you will fear.
What one fears, one destroys."
Chief Dan George
"A cheerful heart is good medicine,
but a crushed spirit dries up the bones".
Proverbs: 17:22
Blessed are all who take refuge in HIM.
Jerry 21: And unto this people thou shalt say,
Thus saith the LORD Of DOG;
Behold, I set before you
The Way Of Life,
And
The Way Of Death.
And Disciple Paulie said unto them, Thus shall ye
say to your master, Thus saith The LORD Of DOG,
Be not afraid of the words which thou hast heard,
with which the servants of koehler and university
trained behaviorists and veterinary malpracticioners
have blasphemed me.
Disciple Paulie Sez:
"No One Understands How Wits End Training Really
Works, They Assume It's All Nicey Nicey And don't
Realise It's A Very Disciplined Method That Deals With
Any Situation And The Foundation Is Built On Trust
And Understanding.
I've never forced my dogs to do anything, I tell them
they are good dogs and they seem to follow me, once
I told them they were bad dogs and they ran away from
me, now I only ever tell them they are good dogs and
they always are, always.
Trust your dog, ask it to do your request and say "good
dog" sincerely at the end of the request and I bet you'll
find your dog thinking then responding everytime.
A bit of respect works wonders, the same rule applies
to every aspect of the relationship with your dog.
Obedience and affection are not related, if they were
everyone would have obedient dogs.
I have found giving dogs "payment" in advance i.e. "Sam
sit goodboy" makes the dogs want to respond, after all,
all dogs want to be "good dogs" and if you tell them they
are good then they feel an obligation to obey your request.
Telling Sam he's a good dog AFTER he sit's apart from
been too late is also a gamble because if he doesn't
sit then there's no positive interaction.
Paul
"Think not that I am come to send peace on earth:
I came not to send peace,
but a sword.
"For I am come to set a man at variance against his father,
and the daughter against her mother,
the daughter in law against her mother in law
and the scholar against his professors.
"And a man's foes shall be they of his own HOWEshold."
The Simply Amazing Puppy Prophet <{); ~ ) >
> Would his ideas actually be more widely accepted?
All truth passes through three stages.
First, it is ridiculed.
Second, it is violently opposed.
Third, it is accepted as being self-evident.
-Arthur Schopenhauer
The lyin dog abusing punk thug coward actuve acute chronic
long term incurable mental cases you're PLAYIN GRABBASS with
call The Freakin Simply Amazing Puppy Wizard's 100% CONSISTENTLY
NEARLY INSTANTLY SUCCESSFUL FREE WWW Wits' End Dog Training
Method Manual Students ALL OVER The WHOWEL WILD WORLD LIARS
and their posts FORGERIES in order to DEFEND jerking choking
shocking bribing crating intimidating and surgically sexually
mutilating innocent defenseless dumb critters <{): ~ ) >
Punishment Deranges Behavior.
"NO!" Does NOT Have Any Behavioral Function
EXCEPT
To DERANGE Behaviors.
Here's professor "SCRUFF SHAKE and SCREAM NO! into ITS face for
five seconds and lock IT in a box for ten minutes contemplation"
dermer of the Department of ANAL-ytic Behavior at UofWI, pryor:
From: Marshall Dermer (der...@alpha1.csd.uwm.edu)
Subject: Re: Jerry's Dog Training Manual
Date: 2001-07-12 06:49:13 PST
And how do we know this aspect of his
advice is right?
Jerry is not God and his manual is not the Bible.
His advice could be subject to an empirical analysis.
(Also, it is best to killfile posts from the
few regulars here who are either ill-tempered,
ill-mannered, or just plain ill.),
--Marshall
Marshall Lev Dermer/ Department of Psychology/ University of
Wisconsin-Milwaukee/ Milwaukee, WI 53201/ der...@uwm.edu
http://www.uwm.edu/~dermer
"Life is just too serious to be taken entirely seriousyl!"
From: der...@alpha1.csd.uwm.edu (Marshall Dermer) -
Date: 1998/08/28
Subject: Re: Puppy growls and snaps
In article <6s6ea0$8c...@uwm.edu> der...@alpha1.csd.uwm.edu (Marshall
Dermer) writes: In article
> >tami sutherland writes:
>> However, there have been incidences where she has
>> growled and snapped at us...for instance, when we
>> were trying to dry her off after bathtime.
> When your three-month old pooch growls or snaps, IMMEDIATELY
> pick her up ONLY by the skin at the back of her neck, for 5
> sec, and loudly say, "NO!" Alternatively, say "NO!" and hold
> her mouth shut for say 15 sec.
> If she so snaps that you can't do the above then you
> will have to find another way to administer a prompt
> correction, for example, throwing a can filled with
> pennies, or a tug on the collar. --Marshall
"Oops! I would start by only holing her mouth
shut for say 5 sec.
At this point, "No" does not have any behavioral function.
But, if you say "No,"pick up the puppy by its neck and
shake it a bit, and the frequency of the biting decreases
then you will have achieved too things.
First, the frequency of unwanted chewing has decreased;
and two, you have established "No" as a conditioned punisher.
How much neck pulling and shaking? Just the
minimum necessary to decrease the unwanted
biting.
**********IS THAT A CONSISTENT 5 SECONDS?************
When our dog was a puppy, "No" came before mild
forms of punishment (I would hold my dog's mouth
closed for a few seconds.) whereas "Bad Dog" came
before stronger punishement (the kind discussed above).
"No" is usually sufficient but sometimes I use "Bad Dog"
to stop a behavior. "Bad Dog" ALWAYS works," marshall
dermer, research professor of ANAL-ytic behaviorISM at
UofWI. For MOORE animal abuse, please visit dr p.
BWAHAHAHHAHAAAA!!!!!
That's INSANE. Ain't it.
P.S. Contacting Dr. P:
Please note that due to the large number of
requests I receive, I can no longer give free,
personal advice on problems related to dog
training and behavior.
In order for me to give such advice we would
have to "talk" about the problem at length.
That is, I would need detailed information about
the dog, it's environment and routine, the problem,
and the situation in which the problem occurs.
Thus, this type of consultation takes time which
I cannot afford to give away for free.
If you wish such advice, please see the information
I have provided about my K9 Behavioral Consulting
practice. Another alternative to obtaining personal
advice is to participate in e-mail, chat room, &
newsgroup discussions.
P.P.S. BWEEEEEEEAHAHAHAHAHAHAHHAAA!!!
YOU'RE FRAUDS, drs p. and dermer!
Either DEFEND your LIES, ABUSE And
Degrees or get the heel HOWETA THIS
BUSINESS.
From: "George von Hilsheimer, Ph.D."
To: "Jerry Howe"
Subject: Alleged Professors of Animal Behavior
Date: Fri, 19 Aug 2005 12:50:51 -0400
Dear Jerry, I paged through some of the "dog business"
and was astonished at the low quality of opinions arising
from professors of behavior analysis.
I had the very great privilege of meeting Sam Corson
(Pavlov's last Ph.D. student) and his dogs at Ohio
University. I even got to spend a night at Sam's house.
There is no question but that you are a spiritual brother
to Corson and to Pavlov, both of whom knew that the dog's
great capacity for love was the key to shaping doggie behavior.
Paradoxical reward and paradoxical fixing of attention are
both well documented Pavlovian techniques. Even so humorless
a chap as B.F. Skinner taught students like the Breland's whose
"The Misbehavior of Organisms" demonstrate the utility of your
methods and their deep roots in scientific (as opposed to
commercial) psychology.
George von Hilsheimer, Ph.D., F.R.S.H.
you may find my resume in Who's Who in
Science and Technology
Here's professor dermer AFTER gettin JERRYIZED:
"We Are Lucky To Have You, And More People Should
Come To Their Senses And Support Your Valuable Work.
God Bless The Puppy Wizard," Professor Marshall Dermer,
Dept Of ANAL-ytic Behavior, UofWI.
From: "Marshall Dermer"
To: "The Puppy Wizard"
Sent: Friday, July 23, 2004 2:53 PM
Subject: God Bless The Puppy Wizard
Dear Mr. Puppy Wizard,
I have, of late, come to recognize your genius
and now must applaud your attempts to save
animals from painful training procedures.
You are indeed a hero, a man of exceptional talent,
who tirelessly devotes his days to crafting posts to
alert the world to animal abuse.
We are lucky to have you, and more people should
come to their senses and support your valuable
work.
Have you thought of establishing a nonprofit
charity to fund your important work?
Have you thought about holding a press conference
so others can learn of your highly worthwhile
and significant work?
In closing, my only suggestion is that you
try to keep your messages short for most
readers may refuse to read a long message
even if it is from the wise, heroic Puppy Wizard.
I wish you well in your endeavors.
--Marshall Dermer
==========
> Is the idea of stress-induced auto-immune disease really so
> farfetched? Isn't it conceivable that mishandling could lead
> to physical symptoms and disease?
HEELTHY CRITTERS DO NOT GET SICK DaveR.
The Freakin Simply Amazing Puppy Wizard SEZ "if it
can't be PREVENTED with gentle tender loving CARE
and apupriate nutrition then it can be FIXED with
Crazy Glue. If it can't be fixed with Crazy Glue
IT CAN'T BE FIXED" <{): ~ ( >
Sam Corson, Pavlov's Last Student Demonstrated At
UofOH, That Rehabilitation Of Hyperactive Dogs Can
Easily And Readily Be Done Using TLC. Tender Loving
Care Is At The Root Of The Scientific Management Of
Doggys <{) ; ~ ) >
To IGNORE THIS is CRIMINAL:
"Every stress leaves an indelible scar, and the
organism pays for its survival after a stressful
situation by becoming a little older," Hans Selye.
Hans Selye
Hans Selye was born in Vienna in 1907. As early as his second
year of medical school (1926), he began developing his now-
famous theory of the influence of stress on people's ability
to cope with and adapt to the pressures of injury and disease.
He discovered that patients with a variety of ailments manifested
many similar symptoms, which he ultimately attributed to their
bodies' efforts to respond to the stresses of being ill.
He called this collection of symptoms--this separate stress
disease--stress syndrome, or the general adaptation syndrome (GAS).
He spent a lifetime in continuing research on GAS and wrote some
30 books and more than 1,500 articles on stress and related problems,
including Stress without Distress (1974) and The Stress of Life (1956).
So impressive have his findings and theories been that
some authorities refer to him as "the Einstein of medicine."
A physician and endocrinologist with many honorary degrees for his
pioneering contributions to science, Selye also served as a professor
and director of the Institute of Experimental Medicine and Surgery at
the University of Montreal.
More than anyone else, Selye has demonstrated the role of emotional
responses in causing or combating much of the wear and tear experienced
by human beings throughout their lives. He died in 1982 in Montreal,
where he had spent 50 years studying the causes and consequences of
stress.
-------------
> I believe so. Too bad the only proponent
> of such a theory is a mental case.
Yeah. LUCKY THING THIS MENTAL CASE GOT THE FORENSIC
EVIDENCE TO PROVE IT despite bein a MENTAL CASE,
DaveR <{); ~ ) >
> Anyone who is even remotely willing to accept such
> a concept is quickly discouraged by the rantings of
> a lunatic.
THAT'S the PREDICTABLE RESULT OF SHAME and GUILT <{); ~ ) >
The Puppy Wizard's SYNDROME Is the Perfect Synergy Of
Love, Pride, Desire, Shame, Greed, Ego, Fear,
Hate, Reflex, Self Will,
Arrogance, Ignorance, Predjudice, Cowardice,
Disbelief, Jealousy, Embarrassment, Embellishment,
Guilt, Anger, Hopelessness, Helplesness,
Aversion, Attraction, Inhibition, Revulsion, Repulsion,
Change, Permanence, Enlightenment, Insult, Attrition,
And
Parental / ReligiHOWES / Societal Conditioning.
YOU ARE THE CRITTER YOU WAS TRAINED.
It Is The Perfect Fusion Of The Word..., In The Physical.
> Personally, I would like to learn how to make my dog
> as happy as she can be, and maybe stave off physical
> problems along the way.
WELCOME To The Freakin Simply Amazing Puppy Wizard's 100%
CONSISTENTLY NEARLY INSTANTLY SUCCESSFUL FREE WWW Wits'
End Dog Training Method Forums.
I'm Jerry Howe, The Simply Amazing Puppy Wizard <{) ; ~ ) >
Here's your own FREE COPY of The Freakin Simply Amazing Puppy
Wizard's 100% CONSISTENTLY NEARLY INSTANTLY SUCCESSFUL FREE
WWW Wits' End Dog Training Method Manual <{) : ~ } >
<{#}: ~ } >8< { ~ :{@}>
<{#}: ~ } > < { ~ :{@}>
<{#}: ~ } > < { ~ :{@}>
<{#}: ~ } > http://www.tinyurl.com/7bl5u < { ~ :{@}>
<{#}: ~ } > < { ~ :{@}>
<{#}: ~ } > < { ~ :{@}>
<{#}: ~ } >8< { ~ :{@}>
Animal Behavior Forensic Sciences Research Laboratory
Subject: Will CLOMICALM change my dog's personality?
HOWEDY judi,
<> wrote in message
> If you guys STOP responding to this jerk PUPPY WIZARD,
You FEAR The Puppy Wizard cause HE will EXXXPOSE YOU
as a dog abuser and a puppy miller. The following
posts will verify that...
Your ABUSE is what's responsible for your dogs being
afflicted by the STRESS INDUCED "amyloid" problem
prevelent in your breed...
> he will not get what he wants
The Puppy Wizard ALWAYS gets whe HE wants.
> which is to rile you all up.
You mean, by EXXXPOSING YOU?
> Just DELETE or BLOCK his emails and go on with the message board.
You mean, stay unaware of the liars and dog
abusers we got postin here abHOWETS, judi?
> In other words....IGNORE HIM!!
Right, cause The Puppy Wizard will prove you
to be a FRAUD a puppymiller and a dog abuser.
> If he doesn't get your goats, he'll go away!
No HE won't be goin away... not till HE EXXXPOSES
you as a dog abusing Punk Thug Coward and puppymiller
you are.
Seems you're OBSESSED by The Puppy Wizard:
> Judi
> From: Blugrass...@webtv.net
Subject: Re: alt. Puppy Wizard?
Date: 2003-06-09 21:45:21 PST
Karen, I have WebTV and cannot "block" emails so
that is why I suggested that people just "ignore" this
Puppy Wizzard. I know some on here who are also
on WebTV.
Either way, the BEST way to get these "trolls" to stop
posting is to ignore them. That BUGS them worse
than anything.
And they go away.
The only reason they troll is to get everyone's dander
up hehe. They're not worth letting this NG disappear.
Have fun everyone!
Judi
From: mnementh (eand...@dwave.net)
Subject: Re: Biting Problem
Date: 1999/06/15
My breeder constantly reminded me about using the
"submissive NO!" as she described it for correcting
inappropriate behavior in my shar pei.
That meant pinning her down on the floor with my
hand (or hands if that's what it took) and holding
her body and head down while giving a stern "NO!".
I even trained my two boys (ages 9 and 6) to do this
because she'd get rough when playing with them.
It worked very well and she is now a very well
behaved dog. Just the verbal "No" is all it takes now.
Elaine
From: Judi Todd (Blugrass...@webtv.net)
Subject: Re: Biting Problem
Date: 1999/06/19
Elaine,
Yes, this is also a good way to establish your
"Alpha" status with the dog. Only thing, I would
not recommend it with a dog who is even the
slightest bit prone to "acting out" ,or biting.
Could i ask who your breeder is? I probably
know her. She sounds like she has given you
some good advise.
Judi
From: Blugrass...@webtv.net (Blugrass...@webtv.net)
Subject: Re: My Pei barks all night !!!
Date: 1999/07/13
I don't know where you heard that a pei cannot sleep
in your bedroom, because of dominance, but whoever
told you that is very wrong.
I have 16 pei in all (some rescues, some breeding stock,
and some retired breeding stock) and 3 of my dogs sleep
with me.
They wouldn't dream ofshowing any dominance to me.
I am Alpha bitch in my house!
Pe should never be allowed to be the boss in
anyone's house. They are the most lovng creatures
I've ever known.
Judi
===============
From: Blugrass...@webtv.net (Blugrass...@webtv.net)
Subject: Re: Shar pei wanted....
Date: 1999/07/04
Frog Man,
Unfortunately, there are NO lines that are amyloid free.
Some are "hotter" than others, and you should avoid those.
I have no pups at the moment, and the litter I have due, are
pretty much spoken for, but if you find a pup, and can forward
it's pedigree to me, I can look it over for you and tell you where
the amyloid in the lines is.
You want to keep it as far back as possible.
Unfortunately, many dogs that die from this, do not
show any signs of it until they are almost dead.
Please contact me and I will try to help you.
Judi
===================
NHOWE on to the GOOD STUFF, the REASONS
YOUR DOGS GET SICK AND DIE:
Familial Shar-Pei Fever (FSF) is a hereditary inflammatory
disorder seen in Shar-Pei. It is inherited as an autosomal
recessive condition. Clinical signs: Episodic fever is the
most important and consistent clinical sign of this disorder.
The temperature commonly is in the 105-107 F range.
The fever is generally self-limiting lasting 12-36 hours.
Another common clinical sign often accompanying the
fever is swelling of a joint, usually the hock (tibiotarsal)
joint and is known as Swollen Hock Syndrome (SHS).
This painful, hot swelling can also involve the carpus
(wrist) AND THE MUZZLE. Dogs with FSF are sick -
- they are reluctant to move and when they do walk
they have a characteristic "walking on eggs" gait.
They often are painful in the abdomen and have a
characteristic "roached" back.
There can be gastrointestinal signs such as
mild vomiting and diarrhea as well.
Pathogenesis: What we do know about this disease
is as follows: 1. Shar-Pei with FSF have increased
levels of the cytokine Interleukin-6 (IL-6).
IL-6 is involved with the fever response and is an integral
part of triggering the production of Acute Phase Reactant
Proteins by the liver.
IL-6 is also involved in the Systemic Inflammatory
Response Syndrome(SIRS). Dysregulation of IL-6
is the cause of much of the disease in Shar-Pei with FSF.
IL-6 also plays a major role in the body's stress response and
serves to "prime" the immune system. 2. Shar-Pei with FSF
are at risk from early death from systemic amyloidosis.
About 25% of the FSF dogs will develop renal amyloidsis -- a
smaller percentage will develop hepatic amyloidosis.
This is usually seen in Shar-Pei between the ages of 2-5
years of age. They also seem more susceptible to immune-mediated
kidney disease such as membranous glomerulonephritis,
protein-losing glomerulopathies, DIC, thromboembolic phenomena
such as mesenteric, splenic and pulmonary embolism and
Streptococcal Toxic Shock Syndrome (STSS).
3. FSF in Shar-Pei seems to be an animal model for Familial
Mediterranean Fever in humans. 4. FSF is a heredofamilial
disease with a genetic basis. It appears to be inherited as an
autosomal recessive condition.
Laboratory Findings: Unfortunately there are no blood tests,
etc. which are specific for FSF. During a fever episode there
will often be an increased white blood cell count, an increase
in liver enzyme levels and other non-specific findings. Work
is underway by Dr. Gary Johnson at the University of Missouri
College of Veterinary Medicine to develop a DNA blood test to
screen for the disease.
Treatment: It is very important to monitor the temperature
in this condition. Initially, fever can be treated using aspirin.
Usually a regular strength adult aspirin is given every 6 hours
for the first 24 hours and then twice a day for 3-5 days
thereafter.
In rare cases where aspirin doesn't work or for extremely
high fevers, dipyrone is given. Some patients will require
supportive care with intravenous fluid therapy and in extreme
cases emergency treatment similar to heat stroke treatment.
Antibiotics are not normally indicated in this condition.
Colchicine:
Colchicine is a drug that has been in use in people with FMF
to prevent amyloidosis. It is currently being recommended in
Shar-Pei with FSF for the same purpose. No studies have been
completed to determine if it NEX
**
*********************
AMYLOIDOSIS:
Amyloidosis is the deposition of an abnormal substance called
amyloid in the tissues of the body. These amyloid deposits
are composed of protein fibrils formed by the polymerization
of protein subunits forming a specific pattern called the
beta-pleated sheet.
The specific biophysical arrangement of this sheet gives
the amyloid deposits their unique staining and optical properties.
Due to this structure amyloid is insoluble and can be
thought of as "wax". It is also important to realize that
amyloidosis is not a single disease, but can be the end
point of many diseases.
The structure of amyloid also is responsible for the
characteristic green color after staining with Congo red.
In Shar-Pei amyloidosis is a reactive amyloidosis. This
form of systemic amyloidosis usually occurs with chronic
inflammatory diseases and is characterized by the presence
of amyloid protein AA.
Amyloid protein AA is derived from an acute phase protein
called serum amyloid A protein (SAA) produced by the liver.
There are many other acute phase proteins produced by
the liver which have important roles in the inflammatory
process and in tissue repair after injury. It is important to
understand that amyloid protein AA is a normal protein and
that it's production is a normal response to tissue injury and
inflammation.
It is also important to realize that many diseases, traumatic
injuries, cancer disorders, stresses, etc. can stimulate the
production of the acute phase proteins.
There appears to be a balance between the production of SAA
and the degradation and excretion of SAA from the body. It is
not known whether the development of amyloidosis in the
Shar-Pei is due to prolonged excessive SAA production by the
liver which overwhelms the degradation mechanisms or a defect
in the degradation process itself, or a combination of both.
We do know that Familial Shar-Pei Fever is an inflammatory
process which does stimulate the synthesis and release of
acute phase proteins from the liver. That this occurs can be
surmised from the changes seen on the hemogram and biochemical
profiles of Shar-Pei during, or shortly after, an
FSF episode.
It certainly appears that the cause of amyloidosis in
Shar-Pei has a genetic basis. Reactive amyloidosis results in
extracellular deposition of amyloid protein in tissues.
This means the "waxy" amyloid is surrounding the cells
and slowly crushes them as well as interfering with nutrition
of the cells. These cells die and the structures they make
up are replaced by fibrous, nonfunctional scar tissue.
There are species differences as to which tissues amyloid
will accumulate in. In dogs, the kidney is the primary organ
involved with the spleen and liver affected less often. The
kidney is especially vulnerable due to its decreased ability
to replace damaged cells and ultimately, when a certain number
of cells have been irreparably damaged, kidney failure with
its accompanying clinical signs develops.
Once amyloid is deposited in the tissues it appears that
nothing can remove it.
Why does amyloidosis have so many different clinical
presentations? Why does it occur in some Shar-Pei at
2 years of age and in others at 10 years of age? Why
do some Shar-Pei develop amyloidosis and others don't?
Why is it a genetic disease in Shar-Pei? There are many
questions which have no answers at this time. I think several
theories are plausible to explain the variations we see: The
underlying basis of amyloidosis in Shar-Pei is Familial Shar-Pei
Fever (FSF).
It is quite possible that FSF has variable age of onset and
variable degrees of severity in terms of the inflammatory
disease it causes. This may result in a variable rate of
progression in the development of amyloidosis in different
individuals. For example, the response of the liver to FSF
and the synthesis and release of the acute phase proteins,
especially SAA, may be more acute in some dogs resulting
in a more rapid deposition of amyloid.
In other individuals, the response to FSF may be more
chromic and result in slower deposition of amyloid.
In effect, there may be milder forms and more severe
forms of the same disease. The exact mechanism
of amyloid deposition may be different in different
individuals. There may be other effects of FSF on the
body which are additive with the amyloidosis.
As an example, we know Shar-Pei are more susceptible to
disseminated intravascular coagulation (internal blood clotting)
during an episode of FSF and blood clots in the kidneys may
cause more kidney damage than just amyloid deposition itself.
Some dogs may have other disease processes going on
which can be additive with the effects of amyloidosis.
These are just some ideas on why we see different
presentations of the same disease. One fact remains -
any amyloid deposits found in a Shar-Pei have to be
regarded as related to FSF and genetic until proven otherwise.
It really doesn't matter whether a little or a large amount
of amyloid is found. Another point to keep in mind is that
the mechanisms initiating amyloid deposition are normal
protective responses seen in any breed of dog.
It appears in our breed that the mechanisms, which
regulate the inflammatory response, don't work properly
allowing this normal response to go out of control and
cause disease.
========================
You can blame all that on STRESS hormones
interluken-6 and cortisol released as a direct
result of your MISHANDLING and ABUSE..
That's HOWE COME you HATE and FEAR The Freakin
Simply Amazing Puppy Wizard. <} ; ~ ) >
date: 8 Apr 2006 23:42:50 -0700
author: unknown
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