"Increase in free reactive iron in psoriasis"

LETTER TO EDITOR

Year : 2008  |  Volume : 74  |  Issue : 3  |  Page : 277-278

Role of free reactive iron in psoriasis

Arpita Ghosh, Soma Mukhopadhyay, Manoj Kar
 Department of Biochemistry, NRS Medical College and Hospital,
Kolkatta, West Bengal, India
Correspondence Address:
Manoj Kar
Department of Biochemistry, NRS Medical College and Hospital,
Kolkatta
India

Source of Support: None, Conflict of Interest: None

How to cite this article:
Ghosh A, Mukhopadhyay S, Kar M. Role of free reactive iron in
psoriasis. Indian J Dermatol Venereol Leprol 2008;74:277-8

How to cite this URL:
Ghosh A, Mukhopadhyay S, Kar M. Role of free reactive iron in
psoriasis. Indian J Dermatol Venereol Leprol [serial online] 2008
[cited 2008 Jun 28];74:277-8. Available from: http://www.ijdvl.com/text.asp?2008/74/3/277/41390


Sir,

Psoriasis is a chronic, inflammatory autoimmune skin disease. [1]
Recently, oxidative stress has been implicated in the etiopathology of
psoriasis. Reduced level of serum super oxide dismutase (SOD),
glutathione peroxidase (GPX), and elevated level of nitric oxide (NO)
has been reported. [2],[3],[4] The causative factor of such oxidative
stress is not yet clearly known. In psoriatic plaque blood capillaries
are dilated and become tortuous to form loops which may cause
breakdown of erythrocytes to release hemoglobin. Moreover, low GPX and
SOD may help to elevate the level of hydrogen peroxide (H 2 O 2 )
which further causes break down of hemoglobin within erythrocyte to
form nonheme reactive iron. This free reactive iron can catalyze Haber-
Weiss reaction and generate deadly damaging hydroxyl radical which in
turn damage cellular constituents. [5]

To investigate whether free reactive iron has any role in secondary
pathogenesis of psoriatic lesion, we sought to study the level of free
reactive iron in stroma free hemolysate. Serum level of cellular
damage marker thiobarbituric acid reacting substance (TBARS), total
thiol, total antioxidant status (TAS), and ferritin were also measured
from blood sample of psoriasis patients by standard methods [Table 1].

Sixteen patients were selected for our study (13 males and 3 females)
and all had stable plaque type psoriasis, two with psoriasic
arthritis. Patients were within the age group of 25-36. The psoriasis
area severity index of the patients ranged from 10 to 60. The mean
level of free reactive iron from stroma free hemolysate (214.91 ìgm/g
of Hb) as compared to that of normal control volunteers (118.15 ìg/g
of Hb) and the cellular damage marker TBARS (3.23 nmol/ml) compare to
that of normal control volunteers (1.31 nmol/ml) were found to highly
significant ( P < 0.001) and significant ( P < 0.05), respectively.
The TAS level was also found to be significantly low (0.6 Trolox
equivalent) when compare to normal control (1.37 Trolox equivalent).
The values of total thiol and ferritin were not statistically
significantly different, but mean values were lower for total thiol
and higher for ferritin.

Ferrous iron with six coordination states is bound and tamed within
protoporphyrin ring of hemoglobin. Under specific circumstances like
oxidative stress or over production of H 2 O 2 , it comes out of the
ring and can ligate with other part of globin chain. This non-heme
iron has been termed free reactive iron which can generate cytotoxic
hydroxyl radical by Fenton reaction in presence of H 2 O 2 . [5]

Our findings indicate the increase in level of free reactive iron and
lower level of antioxidant status in psoriasis. This may contribute
via free radical generation to the development of secondary cellular
damage and pathological state in psoriasis vulgaris. Therapeutic use
of iron chelator and antioxidant drugs may be investigated for
beneficial role in psoriasis.

   References

1. Davidson. Psoriasis. In : Principles and Practice of Medicine. 18
ed. 2002. p. 900.
2. Wang H, Peters T, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N,
et al. Activated macrophages are essential in murine model for T-cell
mediated chronic Psoriasiform skin inflammation. J Clin Invest
2006;116:2105-14.    [PUBMED]  [FULLTEXT]
3. Yildirim M, Inaloz HS, Baysal V, Delibas N. The role of oxidants
and antioxidants in Psoriasis. J Eur Acad Dermatol Venereol
2003;17:34-6.    [PUBMED]  [FULLTEXT]
4. Trouba KJ, Hamadeh HK, Amin RP, Germolec DR. Oxidative stress and
its role in skin disease. Antioxid Redox Signal 2002;4:665-73.
[PUBMED]  [FULLTEXT]
5. Gokhale NR, Belgaumkar VA, Pandit DP, Deshpande S, Damle DK. A
study of serum nitric oxide level in psoriasis. Indian J Dermatol
Venereol Leprol 2005;71:175-8.

---------------------------------------

Acta Derm Venereol. 2004;84(1):2-5. Related Articles, Links


In vivo assessment of iron and ascorbic acid in psoriatic dermis.


Leveque N, Robin S, Muret P, Mac-Mary S, Makki S, Berthelot A,
Kantelip JP,
Humbert P.


Laboratory of Cutaneous Bioengineering, Faculty of Medicine and
Pharmacy,
Besancon, France.


Reactive oxygen species play an important role in inflammatory skin
diseases
such as psoriasis. Reactive oxygen species synthesis is catalysed by
iron and
some species are scavenged by ascorbic acid. The aim of this work was
to assess
iron and ascorbic acid in uninvolved and involved psoriatic dermis and
to
compare the corresponding concentrations in the dermis of healthy
subjects.
Microdialysis associated with atomic absorption spectrometry and gas
chromatography-mass spectrometry was used to assess iron and ascorbic
acid,
respectively. Seven psoriatic patients and five healthy volunteers
were
studied. Iron concentrations in the involved (57.1  19.3 microg/l)
and
uninvolved (49.7  27.1 microgl/l) psoriatic dermis were higher than
the
corresponding value determined in the dermis of healthy subjects (21.8
 2.4
microg/l) (p<0.05). Ascorbic acid in involved (47.3  8.2 microg/ml)
and
uninvolved (42.0  14.0 microg/ml) psoriatic dermis was
statistically lower
than that found in healthy dermis (176.8  29.0 microg/ml) (p<0.05).
These
results demonstrate that psoriatic patients exhibit high iron and low
ascorbic
acid concentrations in the dermis, but there were no significant
differences
between involved and uninvolved skin.


PMID: 15040469 [PubMed - indexed for MEDLINE]


--------------------------------------------------------------------------
------



Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


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http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

On Sat, 28 Jun 2008 06:39:06 -0700 (PDT), ironjustice
 wrote:

>"Increase in free reactive iron in psoriasis"

No amount of complaining over the years to both telus and google
groups seems to have stop this Troll, even being ignored
internationally doesn't seem to stop him, I suspect he must be related
to  Mugabe for his shear insistance that he is right and the rest of
the planet is wrong, either that or he has a screw loose!

On Jun 28, 6:39 am, ironjustice  wrote:
psoriatic patients exhibit high iron and low ascorbic acid
concentrations in the dermis <<

This is precisely what the researchers found in their ..
accidentally .. poisoned mice.

http://tinyurl.com/4uex2a

They found something in the chow they are feeding their mice leads to
"high iron and low ascorbic acid concentrations in the dermis" ..
which leads to increased uroporphyrins in the body / increased lactate
dehydrogenase which is a sign of hemolysis / destruction of red blood
cells.

Sooo .. the researchers from India believe a high red blood cell
breakdown causes a high iron low vitamin C content in the skin of
psoriasis AND .. **we** know  giving strange chow to a mouse gives the
same "high iron and low ascorbic acid concentrations in the
dermis" .. ? .. means .. ?

Is it .. our .. chow / polycythemia .. which causes psoriasis .. ?


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk





> "Increase in free reactive iron in psoriasis"
>
> LETTER TO EDITOR
>
> Year : 2008  |  Volume : 74  |  Issue : 3  |  Page : 277-278
>
> Role of free reactive iron in psoriasis
>
> Arpita Ghosh, Soma Mukhopadhyay, Manoj Kar
>  Department of Biochemistry, NRS Medical College and Hospital,
> Kolkatta, West Bengal, India
> Correspondence Address:
> Manoj Kar
> Department of Biochemistry, NRS Medical College and Hospital,
> Kolkatta
> India
>
> Source of Support: None, Conflict of Interest: None
>
> How to cite this article:
> Ghosh A, Mukhopadhyay S, Kar M. Role of free reactive iron in
> psoriasis. Indian J Dermatol Venereol Leprol 2008;74:277-8
>
> How to cite this URL:
> Ghosh A, Mukhopadhyay S, Kar M. Role of free reactive iron in
> psoriasis. Indian J Dermatol Venereol Leprol [serial online] 2008
> [cited 2008 Jun 28];74:277-8. Available from:http://www.ijdvl.com/text.asp?2008/74/3/277/41390
>
> Sir,
>
> Psoriasis is a chronic, inflammatory autoimmune skin disease. [1]
> Recently, oxidative stress has been implicated in the etiopathology of
> psoriasis. Reduced level of serum super oxide dismutase (SOD),
> glutathione peroxidase (GPX), and elevated level of nitric oxide (NO)
> has been reported. [2],[3],[4] The causative factor of such oxidative
> stress is not yet clearly known. In psoriatic plaque blood capillaries
> are dilated and become tortuous to form loops which may cause
> breakdown of erythrocytes to release hemoglobin. Moreover, low GPX and
> SOD may help to elevate the level of hydrogen peroxide (H 2 O 2 )
> which further causes break down of hemoglobin within erythrocyte to
> form nonheme reactive iron. This free reactive iron can catalyze Haber-
> Weiss reaction and generate deadly damaging hydroxyl radical which in
> turn damage cellular constituents. [5]
>
> To investigate whether free reactive iron has any role in secondary
> pathogenesis of psoriatic lesion, we sought to study the level of free
> reactive iron in stroma free hemolysate. Serum level of cellular
> damage marker thiobarbituric acid reacting substance (TBARS), total
> thiol, total antioxidant status (TAS), and ferritin were also measured
> from blood sample of psoriasis patients by standard methods [Table 1].
>
> Sixteen patients were selected for our study (13 males and 3 females)
> and all had stable plaque type psoriasis, two with psoriasic
> arthritis. Patients were within the age group of 25-36. The psoriasis
> area severity index of the patients ranged from 10 to 60. The mean
> level of free reactive iron from stroma free hemolysate (214.91 ìgm/g
> of Hb) as compared to that of normal control volunteers (118.15 ìg/g
> of Hb) and the cellular damage marker TBARS (3.23 nmol/ml) compare to
> that of normal control volunteers (1.31 nmol/ml) were found to highly
> significant ( P < 0.001) and significant ( P < 0.05), respectively.
> The TAS level was also found to be significantly low (0.6 Trolox
> equivalent) when compare to normal control (1.37 Trolox equivalent).
> The values of total thiol and ferritin were not statistically
> significantly different, but mean values were lower for total thiol
> and higher for ferritin.
>
> Ferrous iron with six coordination states is bound and tamed within
> protoporphyrin ring of hemoglobin. Under specific circumstances like
> oxidative stress or over production of H 2 O 2 , it comes out of the
> ring and can ligate with other part of globin chain. This non-heme
> iron has been termed free reactive iron which can generate cytotoxic
> hydroxyl radical by Fenton reaction in presence of H 2 O 2 . [5]
>
> Our findings indicate the increase in level of free reactive iron and
> lower level of antioxidant status in psoriasis. This may contribute
> via free radical generation to the development of secondary cellular
> damage and pathological state in psoriasis vulgaris. Therapeutic use
> of iron chelator and antioxidant drugs may be investigated for
> beneficial role in psoriasis.
>
>    References
>
> 1. Davidson. Psoriasis. In : Principles and Practice of Medicine. 18
> ed. 2002. p. 900.
> 2. Wang H, Peters T, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N,
> et al. Activated macrophages are essential in murine model for T-cell
> mediated chronic Psoriasiform skin inflammation. J Clin Invest
> 2006;116:2105-14.    [PUBMED]  [FULLTEXT]
> 3. Yildirim M, Inaloz HS, Baysal V, Delibas N. The role of oxidants
> and antioxidants in Psoriasis. J Eur Acad Dermatol Venereol
> 2003;17:34-6.    [PUBMED]  [FULLTEXT]
> 4. Trouba KJ, Hamadeh HK, Amin RP, Germolec DR. Oxidative stress and
> its role in skin disease. Antioxid Redox Signal 2002;4:665-73.
> [PUBMED]  [FULLTEXT]
> 5. Gokhale NR, Belgaumkar VA, Pandit DP, Deshpande S, Damle DK. A
> study of serum nitric oxide level in psoriasis. Indian J Dermatol
> Venereol Leprol 2005;71:175-8.
>
> ---------------------------------------
>
> Acta Derm Venereol. 2004;84(1):2-5. Related Articles, Links
>
> In vivo assessment of iron and ascorbic acid in psoriatic dermis.
>
> Leveque N, Robin S, Muret P, Mac-Mary S, Makki S, Berthelot A,
> Kantelip JP,
> Humbert P.
>
> Laboratory of Cutaneous Bioengineering, Faculty of Medicine and
> Pharmacy,
> Besancon, France.
>
> Reactive oxygen species play an important role in inflammatory skin
> diseases
> such as psoriasis. Reactive oxygen species synthesis is catalysed by
> iron and
> some species are scavenged by ascorbic acid. The aim of this work was
> to assess
> iron and ascorbic acid in uninvolved and involved psoriatic dermis and
> to
> compare the corresponding concentrations in the dermis of healthy
> subjects.
> Microdialysis associated with atomic absorption spectrometry and gas
> chromatography-mass spectrometry was used to assess iron and ascorbic
> acid,
> respectively. Seven psoriatic patients and five healthy volunteers
> were
> studied. Iron concentrations in the involved (57.1  19.3 microg/l)
> and
> uninvolved (49.7  27.1 microgl/l) psoriatic dermis were higher than
> the
> corresponding value determined in the dermis of healthy subjects (21.8
>  2.4
> microg/l) (p<0.05). Ascorbic acid in involved (47.3  8.2 microg/ml)
> and
> uninvolved (42.0  14.0 microg/ml) psoriatic dermis was
> statistically lower
> than that found in healthy dermis (176.8  29.0 microg/ml) (p<0.05).
> These
> results demonstrate that psoriatic patients exhibit high iron and low
> ascorbic
> acid concentrations in the dermis, but there were no significant
> differences
> between involved and uninvolved skin.
>
> PMID: 15040469 [PubMed - indexed for MEDLINE]
>
> -------------------------------------------------------------------------> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

On Jun 28, 8:30 am, ironjustice 
wrote:psoriatic patients exhibit high iron and low ascorbic acid
concentrations in the dermis <<

"It may suggest that there is a relationship between the two
diseases."

Case Report

The Coexistence of Photosensitive Psoriasis with Chronic Actinic
Dermatitis
Bijaylaxmi Sahoo, Bhushan Kumar

Department of Dermatology, Venereology and Leprology, Postgraduate
Institute of Medical Education and Research, Chandigarh, India


Address of Corresponding Author

Dermatology 2002;204:77-79 (DOI: 10.1159/000051817)


---------------------------------------------------------------------------  Key Words

Photosensitivity
Chronic actinic dermatitis
Photosensitive psoriasis

---------------------------------------------------------------------------  Abstract

A 57-year-old-male who had been a known case of psoriasis vulgaris for
30 years had a history of summer exacerbation of the disease.
Subsequently in the course of the disease process, he developed
lesions of chronic actinic dermatitis (CAD) on the face and dorsum of
both hands. The association of CAD with photosensitive psoriasis is
very rare. Only one case report is known till now. It may suggest that
there is a relationship between the two diseases.

Copyright © 2002 S. Karger AG, Basel


---------------------------------------------------------------------------  Author Contacts

Prof. Dr. Bhushan Kumar
Department of Dermatology, Venereology and Leprology
PGIMER
Chandigarh (India)
Fax  172 744401, E-Mail kumarbhushan@hotmail.com


---------------------------------------------------------------------------  Article Information

Received: Received: August 11, 2000
Accepted: August 9, 2001


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/4rq595


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk




> On Jun 28, 6:39 am, ironjustice  wrote:
> psoriatic patients exhibit high iron and low ascorbic acid
> concentrations in the dermis <<
>
> This is precisely what the researchers found in their ..
> accidentally .. poisoned mice.
>
> http://tinyurl.com/4uex2a
>
> They found something in the chow they are feeding their mice leads to
> "high iron and low ascorbic acid concentrations in the dermis" ..
> which leads to increased uroporphyrins in the body / increased lactate
> dehydrogenase which is a sign of hemolysis / destruction of red blood
> cells.
>
> Sooo .. the researchers from India believe a high red blood cell
> breakdown causes a high iron low vitamin C content in the skin of
> psoriasis AND .. **we** know  giving strange chow to a mouse gives the
> same "high iron and low ascorbic acid concentrations in the
> dermis" .. ? .. means .. ?
>
> Is it .. our .. chow / polycythemia .. which causes psoriasis .. ?
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/4rq595
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > "Increase in free reactive iron in psoriasis"
>
> > LETTER TO EDITOR
>
> > Year : 2008  |  Volume : 74  |  Issue : 3  |  Page : 277-278
>
> > Role of free reactive iron in psoriasis
>
> > Arpita Ghosh, Soma Mukhopadhyay, Manoj Kar
> >  Department of Biochemistry, NRS Medical College and Hospital,
> > Kolkatta, West Bengal, India
> > Correspondence Address:
> > Manoj Kar
> > Department of Biochemistry, NRS Medical College and Hospital,
> > Kolkatta
> > India
>
> > Source of Support: None, Conflict of Interest: None
>
> > How to cite this article:
> > Ghosh A, Mukhopadhyay S, Kar M. Role of free reactive iron in
> > psoriasis. Indian J Dermatol Venereol Leprol 2008;74:277-8
>
> > How to cite this URL:
> > Ghosh A, Mukhopadhyay S, Kar M. Role of free reactive iron in
> > psoriasis. Indian J Dermatol Venereol Leprol [serial online] 2008
> > [cited 2008 Jun 28];74:277-8. Available from:http://www.ijdvl.com/text.asp?2008/74/3/277/41390
>
> > Sir,
>
> > Psoriasis is a chronic, inflammatory autoimmune skin disease. [1]
> > Recently, oxidative stress has been implicated in the etiopathology of
> > psoriasis. Reduced level of serum super oxide dismutase (SOD),
> > glutathione peroxidase (GPX), and elevated level of nitric oxide (NO)
> > has been reported. [2],[3],[4] The causative factor of such oxidative
> > stress is not yet clearly known. In psoriatic plaque blood capillaries
> > are dilated and become tortuous to form loops which may cause
> > breakdown of erythrocytes to release hemoglobin. Moreover, low GPX and
> > SOD may help to elevate the level of hydrogen peroxide (H 2 O 2 )
> > which further causes break down of hemoglobin within erythrocyte to
> > form nonheme reactive iron. This free reactive iron can catalyze Haber-
> > Weiss reaction and generate deadly damaging hydroxyl radical which in
> > turn damage cellular constituents. [5]
>
> > To investigate whether free reactive iron has any role in secondary
> > pathogenesis of psoriatic lesion, we sought to study the level of free
> > reactive iron in stroma free hemolysate. Serum level of cellular
> > damage marker thiobarbituric acid reacting substance (TBARS), total
> > thiol, total antioxidant status (TAS), and ferritin were also measured
> > from blood sample of psoriasis patients by standard methods [Table 1].
>
> > Sixteen patients were selected for our study (13 males and 3 females)
> > and all had stable plaque type psoriasis, two with psoriasic
> > arthritis. Patients were within the age group of 25-36. The psoriasis
> > area severity index of the patients ranged from 10 to 60. The mean
> > level of free reactive iron from stroma free hemolysate (214.91 ìgm/g
> > of Hb) as compared to that of normal control volunteers (118.15 ìg/g
> > of Hb) and the cellular damage marker TBARS (3.23 nmol/ml) compare to
> > that of normal control volunteers (1.31 nmol/ml) were found to highly
> > significant ( P < 0.001) and significant ( P < 0.05), respectively.
> > The TAS level was also found to be significantly low (0.6 Trolox
> > equivalent) when compare to normal control (1.37 Trolox equivalent).
> > The values of total thiol and ferritin were not statistically
> > significantly different, but mean values were lower for total thiol
> > and higher for ferritin.
>
> > Ferrous iron with six coordination states is bound and tamed within
> > protoporphyrin ring of hemoglobin. Under specific circumstances like
> > oxidative stress or over production of H 2 O 2 , it comes out of the
> > ring and can ligate with other part of globin chain. This non-heme
> > iron has been termed free reactive iron which can generate cytotoxic
> > hydroxyl radical by Fenton reaction in presence of H 2 O 2 . [5]
>
> > Our findings indicate the increase in level of free reactive iron and
> > lower level of antioxidant status in psoriasis. This may contribute
> > via free radical generation to the development of secondary cellular
> > damage and pathological state in psoriasis vulgaris. Therapeutic use
> > of iron chelator and antioxidant drugs may be investigated for
> > beneficial role in psoriasis.
>
> >    References
>
> > 1. Davidson. Psoriasis. In : Principles and Practice of Medicine. 18
> > ed. 2002. p. 900.
> > 2. Wang H, Peters T, Kess D, Sindrilaru A, Oreshkova T, Van Rooijen N,
> > et al. Activated macrophages are essential in murine model for T-cell
> > mediated chronic Psoriasiform skin inflammation. J Clin Invest
> > 2006;116:2105-14.    [PUBMED]  [FULLTEXT]
> > 3. Yildirim M, Inaloz HS, Baysal V, Delibas N. The role of oxidants
> > and antioxidants in Psoriasis. J Eur Acad Dermatol Venereol
> > 2003;17:34-6.    [PUBMED]  [FULLTEXT]
> > 4. Trouba KJ, Hamadeh HK, Amin RP, Germolec DR. Oxidative stress and
> > its role in skin disease. Antioxid Redox Signal 2002;4:665-73.
> > [PUBMED]  [FULLTEXT]
> > 5. Gokhale NR, Belgaumkar VA, Pandit DP, Deshpande S, Damle DK. A
> > study of serum nitric oxide level in psoriasis. Indian J Dermatol
> > Venereol Leprol 2005;71:175-8.
>
> > ---------------------------------------
>
> > Acta Derm Venereol. 2004;84(1):2-5. Related Articles, Links
>
> > In vivo assessment of iron and ascorbic acid in psoriatic dermis.
>
> > Leveque N, Robin S, Muret P, Mac-Mary S, Makki S, Berthelot A,
> > Kantelip JP,
> > Humbert P.
>
> > Laboratory of Cutaneous Bioengineering, Faculty of Medicine and
> > Pharmacy,
> > Besancon, France.
>
> > Reactive oxygen species play an important role in inflammatory skin
> > diseases
> > such as psoriasis. Reactive oxygen species synthesis is catalysed by
> > iron and
> > some species are scavenged by ascorbic acid. The aim of this work was
> > to assess
> > iron and ascorbic acid in uninvolved and involved psoriatic dermis and
> > to
> > compare the corresponding concentrations in the dermis of healthy
> > subjects.
> > Microdialysis associated with atomic absorption spectrometry and gas
> > chromatography-mass spectrometry was used to assess iron and ascorbic
> > acid,
> > respectively. Seven psoriatic patients and five healthy volunteers
> > were
> > studied. Iron concentrations in the involved (57.1  19.3 microg/l)
> > and
> > uninvolved (49.7  27.1 microgl/l) psoriatic dermis were higher than
> > the
> > corresponding value determined in the dermis of healthy subjects (21.8
> >  2.4
> > microg/l) (p<0.05). Ascorbic acid in involved (47.3  8.2 microg/ml)
> > and
> > uninvolved (42.0  14.0 microg/ml) psoriatic dermis was
> > statistically lower
> > than that found in healthy dermis (176.8  29.0 microg/ml) (p<0.05).
> > These
> > results demonstrate that psoriatic patients exhibit high iron and low
> > ascorbic
> > acid concentrations in the dermis, but there were no significant
> > differences
> > between involved and uninvolved skin.
>
> > PMID: 15040469 [PubMed - indexed for MEDLINE]
>
> > -----------------------------------------------------------------------> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/4rq595
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -